Domino's Medium Pepperoni Pizza Calories
800 calories per serving
Pizza
A standard serving of Domino's Medium Pepperoni Pizza (2 slices of an 8-slice hand-tossed medium pie) contains approximately 800 calories, making it a calorie-dense meal driven largely by refined dough, cheese, and cured meat. The sodium content is particularly high — nearly 2,000 mg per 2-slice serving — so it's worth watching your intake if you're managing blood pressure or following a low-sodium diet. Choosing thin crust, lighter cheese, and veggie toppings are easy swaps that can meaningfully reduce the calorie and fat load.
Protein
36g
18% of calories
Carbs
88g
44% of calories
Fat
32g
36% of calories
Ingredient Breakdown
| Ingredient | Calories | Protein | Carbs |
|---|---|---|---|
| Hand-Tossed Pizza Dough (2 slices) | 320 | 10g | 62g |
| Marinara/Pizza Sauce (4 tbsp) | 40 | 1g | 8g |
| Whole-Milk Mozzarella Cheese (2 oz) | 220 | 14g | 2g |
| Pepperoni Slices (~18 slices) | 160 | 8g | 1g |
| Garlic Oil / Crust Seasoning | 45 | 0g | 1g |
| Oregano & Spice Blend | 5 | 0.2g | 1g |
| Total | 800 | 36g | 88g |
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Domino's Medium Veggie Pizza on Thin Crust (2 slices)
Save ~320 calories by switching to thin crust and swapping pepperoni for vegetables
Domino's Medium Chicken & Spinach on Thin Crust (2 slices)
Save ~280 calories while boosting protein and reducing saturated fat
Domino's Pacific Veggie on Hand-Tossed (2 slices)
Save ~180 calories and significantly cut sodium versus the pepperoni version
Domino's Stuffed Cheesy Bread replaced with a side salad + 1 slice pepperoni pizza
Save ~350 calories by pairing just 1 slice with a filling, fiber-rich garden salad
Portion Tips
- 1.
Stick to 2 slices as a serving and pair with a large side salad to increase fiber and satiety without piling on pizza calories.
- 2.
Order thin crust instead of hand-tossed — it saves roughly 50–70 calories per slice before any topping changes.
- 3.
Request 'light cheese' when customizing your order online; this can cut 30–50 calories per slice while keeping the flavor.
- 4.
Use Domino's online nutrition calculator before ordering to compare crust, sauce, and topping combinations for your specific order.
- 5.
Avoid eating straight from the box — plate your slices in advance so you have a clear visual of your portion before you start eating.
Common Questions About Domino's Medium Pepperoni Pizza
How many calories are in 2 slices of Domino's medium pepperoni pizza?
Two slices of Domino's medium hand-tossed pepperoni pizza contain approximately 800 calories, along with around 32g of fat and 88g of carbohydrates. Exact values can vary slightly based on crust thickness and regional recipe differences.
Is Domino's thin crust pepperoni pizza lower in calories?
Yes — Domino's thin crust is significantly lower in calories. Two slices of a medium thin-crust pepperoni pizza come in at roughly 560–600 calories, saving you around 200 calories compared to the hand-tossed version, primarily by reducing the dough.
How much sodium is in Domino's medium pepperoni pizza?
A 2-slice serving of Domino's medium hand-tossed pepperoni pizza contains an estimated 1,900–2,000 mg of sodium — nearly the entire recommended daily limit of 2,300 mg for most adults. The pepperoni and cheese are the primary sodium contributors.
How many slices of Domino's medium pizza should I eat on a diet?
For most calorie-conscious diets, 1–2 slices paired with a vegetable-based side (like a salad or roasted veggies) is a reasonable approach. One slice of the hand-tossed pepperoni pizza is approximately 400 calories, making it easier to fit into a 1,500–2,000 calorie daily target.