Pepperoni Pizza (1 Slice) Calories
285 calories per serving
Pizza
One slice of pepperoni pizza from a standard large (14-inch) pie contains approximately 285 calories, making it a moderately energy-dense choice that can add up quickly if you have more than one or two slices. The biggest nutritional watch-outs are sodium and saturated fat — both contributed heavily by the pepperoni and cheese. Crust thickness, cheese quantity, and restaurant vs. homemade preparation can swing calorie counts by 100 calories or more per slice, so these figures are best used as a general guide.
Protein
12g
17% of calories
Carbs
34g
48% of calories
Fat
11g
35% of calories
Ingredient Breakdown
| Ingredient | Calories | Protein | Carbs |
|---|---|---|---|
| Pizza Dough / Crust (1 slice, ~50g) | 130 | 4g | 26g |
| Tomato Pizza Sauce (~3 tbsp) | 20 | 0.8g | 4g |
| Mozzarella Cheese (~1.25 oz) | 90 | 6g | 1g |
| Pepperoni (~7 slices, 1 oz) | 35 | 1g | 0g |
| Olive Oil (brush on crust, ~0.5 tsp) | 10 | 0g | 0g |
| Total | 285 | 12g | 34g |
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Start your free trialHealthier Alternatives
Veggie Pizza Slice (no pepperoni, extra veggies)
Save ~75 calories and significantly reduce saturated fat and sodium by swapping pepperoni for bell peppers, mushrooms, and onions.
Thin-Crust Pepperoni Pizza Slice
Save ~65 calories per slice by choosing thin crust over regular hand-tossed, while keeping the same toppings.
Cauliflower-Crust Pepperoni Pizza Slice
Save ~85 calories and reduce carbs by ~12g per slice with a cauliflower crust base — also a good option for lower-carb eaters.
Homemade Whole-Wheat Pepperoni Pizza Slice
Save ~45 calories, add 3–4g of extra fiber, and control sodium by making pizza at home with a whole-wheat crust and reduced-fat mozzarella.
Portion Tips
- 1.
Use the 'two-slice rule' as a starting point — two slices of a standard large pizza alongside a side salad creates a balanced, satisfying meal without overdoing calories.
- 2.
Blot your pizza slice with a napkin before eating; this simple trick can absorb excess grease and remove 20–40 calories of fat per slice.
- 3.
Load up with a vegetable-based appetizer or side salad first — filling up on fiber and water-rich foods before your pizza naturally helps you eat fewer slices.
- 4.
Opt for thinner slices or ask for your pizza to be cut into more pieces (e.g., 10 slices instead of 8 from a large pie) to reduce per-slice calorie intake without feeling deprived.
- 5.
Be mindful of dipping sauces — a single serving of ranch or garlic butter dip can add 100–150 calories on top of each slice.
Common Questions About Pepperoni Pizza (1 Slice)
How many calories are in 2 slices of pepperoni pizza?
Two slices of a standard large pepperoni pizza contain approximately 570 calories, along with roughly 24g of protein, 68g of carbs, and 22g of fat. Keep in mind that calories can vary significantly based on crust thickness and how generously the pizza is topped with cheese and pepperoni.
Is pepperoni pizza high in sodium?
Yes — a single slice of pepperoni pizza can contain 600–750mg of sodium, largely from the pepperoni, cheese, and pizza sauce. This represents roughly 26–33% of the recommended daily sodium intake of 2,300mg. People monitoring blood pressure or on a low-sodium diet should be especially mindful of portion sizes.
How does restaurant pepperoni pizza compare to frozen pizza in calories?
Restaurant slices (especially from pizza chains) tend to be larger and more generously topped, typically ranging from 250–400 calories per slice. Frozen pizza slices are often smaller, ranging from 200–310 calories, but can be higher in sodium due to preservatives. Always check the nutrition label on frozen pizzas, as serving sizes vary by brand.
Can pepperoni pizza fit into a weight loss diet?
Yes — in moderation. Pizza doesn't need to be off-limits when managing weight. Sticking to one or two slices, pairing with a large green salad, choosing thinner crusts, and opting for less cheese or turkey pepperoni are practical strategies to enjoy pizza while maintaining a calorie deficit. Consistency in overall eating patterns matters far more than any single meal.